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10.核心部件：凈化裝置（浩瀚色譜研制，）

藥典二氧化碳中碳氫化合物色譜測定 測試譜圖：



Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide
Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide Details:

Carbon dioxide Eryanghuatan Carbon DioxideCO2 44.01
This product contains not less than 99.5% CO2 (ml/ml).
【Properties】 This product is a colorless gas; odorless; aqueous solution is weakly acidic.
This product 1 can be dissolved in water at about 1 °C at normal pressure.
[Identification] (1) Take this product and pass it into the barium hydroxide test solution to form a white precipitate; the precipitate can be dissolved in acetic acid and bubbled.
(2) This product can extinguish the flame.
(3) The infrared absorption spectrum of this product should be consistent with the control map (Figure 1) (General Rule 0402).
[Check] Take 100ml of acidity, add 0.2ml of methyl orange indicator solution, mix well, take 50ml each, separate two colorimetric tubes of armor and B, add hydrochloric acid titration solution (0.01ml/L) in the tube. 1.0ml, shake well; in the tube, after entering 1000ml of this product (speed is 4000ml per hour), the red color should not be deeper than the tube.
Moisture Take this product and measure it with a dew point analyzer. The moisture content should not exceed 67 parts per million.
- Chlorinated carbon Take this product and measure it with carbon monoxide detector tube. The carbon monoxide should not exceed 5 parts per million.
Sulfur Dioxide Take this product and measure it with sulfur dioxide detection tube. The sulfur dioxide should not exceed 2 parts per million.
Phosphine is taken from this product and measured with a phosphine detector tube. The phosphine containing hydrogen should not exceed 3 parts per million.
Hydrogen sulfide Take this product and measure it with hydrogen sulfide detection tube. The hydrogen sulfide content should not exceed one part per million.
Ammonia Take this product and measure it with ammonia test tube. The ammonia content should not exceed 25 parts per million.
Hydrocarbon is taken as the test gas, and a gas with a methane content of 0.0020% (with nitrogen as a diluent) is used as a control gas, and gas chromatography (General Rule 0521) is used to test the column with glass spheres as a filler ( 4mm × 0.8m, 80 mesh); column temperature is 110 ° C; inlet temperature is 110 ° C; detector is flame ionization detector, temperature is 120 ° C. The test gas and the control gas are measured and injected into the chromatograph. The peak area measured at the purification temperature of 360 ° C is the corresponding blank value; the gas for the test sample and the control gas are taken, injected into the chromatograph, and the peak area is measured and reduced. The peak area after the corresponding blank value is the corrected peak area. According to the external standard method, the hydrocarbon content (in terms of methane) should not exceed 0.0020%.
[Content determination] In the method of oxygen, except that the absorber shown in the figure is used, and 125ml of potassium hydroxide solution (1→2) is used instead of copper wire and ammonia-ammonium chloride solution as the absorption liquid, and The acidified water (acidic to the methyl orange indicator liquid) is replaced by a saturated sodium chloride solution into the balance bottle J, and operated according to the law until the remaining gas volume is constant. Read the liquid level scale in the trachea and calculate the content of the test sample.


The determination of hydrocarbons in the Pharmacopoeia carbon dioxide is crude and many pharmaceutical companies are difficult to operate. Tengzhou Haohao Chromatography Instrument Technology Service Co., Ltd. keeps pace with the times and develops the determination of hydrocarbons in the Pharmacopoeia CO2 under the guidance of the scientific development concept. Detailed analysis plan, welcome to consult and negotiate.
The specific configuration is as follows:
1.GC-7990 Gas Chromatograph
2. Hydrogen flame detector FID
3. Gas sampling device
4. Standard gas: CH4/N2
5. Packed column: 1m*1/8 (Agilent, Shimadzu. Used for thermoelectric and imported instruments), 0.8m*4mm, 0.8*3mm (for domestic instruments)
6. Hydrogen generator HHH-300
7. Air generator: HHA-3L
8. Nitrogen cylinder and pressure reducing valve
9. Computer, printer
10. Core components: purification device (the development of vast chromatography, domestic original)


Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide Test Spectra: